THAP4

Across TCGA patient cohorts, THAP4 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible THAP4-associated genes across cancer lineages are p90 RSK, STAT3_pY705, and Tuberin. Each is linked with THAP4 in more than 1 cancer types. Because this analysis shows association rather than direction, both THAP4-to-partner and partner-to-THAP4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p90 RSK grouped by THAP4-low versus THAP4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (THAP4→partner) and Y-score (partner→THAP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p90 RSK →	+0.183	+1.887	.040	.031	3	1
UCEC	STAT3_pY705 →	-0.432	-3.159	<.001	.019	3	1
UCEC	Tuberin →	+0.356	+2.179	.004	.034	3	1
UCEC	ASNS →	+0.451	+2.321	.007	.034	3	1
UCEC	4E-BP1 →	+0.330	+3.199	.009	.009	3	1
UCEC	eIF4E →	+0.203	+2.584	.039	.011	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

p90 RSK by THAP4 expression — UCEC

Explore this box plot interactively →