THAP4

Across TCGA cell cohorts, THAP4 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,497 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible THAP4-associated GO terms across cancer lineages are Mitotic sister chromatid separation, Thymidine biosynthetic process, and 2'-deoxyribonucleoside biosynthetic process. Each is linked with THAP4 in more than 11 cancer types. Because this analysis shows association rather than direction, both THAP4-to-partner and partner-to-THAP4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Mitotic sister chromatid separation grouped by THAP4-low versus THAP4-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (THAP4→partner) and Y-score (partner→THAP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Mitotic sister chromatid separation →	+0.166	+0.843	<.001	.001	3	12
SKIN	Thymidine biosynthetic process →	+0.148	+0.778	<.001	<.001	3	11
SKIN	2'-deoxyribonucleoside biosynthetic process →	+0.148	+0.778	<.001	<.001	3	11
SKIN	Pyrimidine deoxyribonucleoside biosynthetic process →	+0.148	+0.778	<.001	<.001	3	11
BONE	Mitochondrial tRNA pseudouridine synthesis →	+0.125	+0.832	<.001	<.001	3	11
BONE	rRNA pseudouridine synthesis →	+0.160	+1.136	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,497 associations by consensus.

Mitotic sister chromatid separation by THAP4 expression — BONE

Explore this box plot interactively →