THAP4

Across TCGA cell cohorts, THAP4 mutation is significantly associated with the RNA expression of many other genes, with 18 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible THAP4-associated genes across cancer lineages are PRKACG, C16orf90, and GFRA4. Each is linked with THAP4 in more than 1 cancer types. Because this analysis shows association rather than direction, both THAP4-to-partner and partner-to-THAP4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRKACG grouped by THAP4-low versus THAP4-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (THAP4→partner) and Y-score (partner→THAP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	PRKACG →	+0.006	+5.087	<.001	.004	3	1
URINARY_TRACT	C16orf90 →	+0.023	+5.087	<.001	.004	3	1
BREAST	GFRA4 →	+0.022	+5.169	<.001	.005	3	1
CNS	C10orf120 →	+0.004	+4.772	<.001	.002	3	1
CNS	LCE5A →	+0.062	+3.874	<.001	.006	3	1
CNS	MAGEB3 →	+0.308	+3.978	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

PRKACG by THAP4 expression — URINARY_TRACT

Explore this box plot interactively →