THAP2

Across TCGA patient cohorts, THAP2 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible THAP2-associated genes across cancer lineages are FoxM1, p27_pT198, and STAT3_pY705. Each is linked with THAP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both THAP2-to-partner and partner-to-THAP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by THAP2-low versus THAP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (THAP2→partner) and Y-score (partner→THAP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.260	+2.584	.031	.011	3	1
UCEC	p27_pT198 →	+0.121	+3.321	.014	.010	3	1
UCEC	STAT3_pY705 →	-0.311	-2.999	.011	.035	3	1
UCEC	Tuberin_pT1462 →	+0.237	+2.179	.028	.034	3	1
UCEC	Caveolin-1 →	-0.717	-2.321	.034	.034	3	1
UCEC	Notch1 →	+0.166	+2.584	.011	.011	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

FoxM1 by THAP2 expression — UCEC

Explore this box plot interactively →