THAP12

Across TCGA pan-cancer cohorts, THAP12 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated THAP12 data layer compared with 26 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher THAP12 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated THAP12 expression acts as an unfavorable survival marker, although some lineages such as PDAC and LUAD show a favorable association.

HNSC, PDAC, and LUAD are the cancer types where THAP12 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	All	0.185	1.000	.010	37	view →
PDAC	DFS	Quartile	III,IV	0.971	0.318	.006	7	view →
LUAD	DFS	Tertile	III,IV	0.982	0.418	.006	7	view →
CCRCC	DFS	Quartile	All	0.841	0.595	.021	6	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

THAP12–HNSC (OS)

Open the HNSC breakdown →