THAP12

Across TCGA patient cohorts, THAP12 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible THAP12-associated genes across cancer lineages are C-Raf, ATM, and Caspase-7-cleavedD198. Each is linked with THAP12 in more than 3 cancer types. Because this analysis shows association rather than direction, both THAP12-to-partner and partner-to-THAP12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C-Raf grouped by THAP12-low versus THAP12-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (THAP12→partner) and Y-score (partner→THAP12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C-Raf →	+0.105	+1.415	.023	.043	3	4
UCEC	ATM →	-0.412	-2.000	.005	.009	3	3
UCEC	Caspase-7-cleavedD198 →	+0.447	+1.926	.020	.008	3	3
UCEC	4E-BP1 →	+0.290	+1.936	<.001	.008	3	3
UCEC	STAT3_pY705 →	-0.339	-2.000	<.001	<.001	3	2
UCEC	eIF4E →	+0.157	+2.415	.021	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

C-Raf by THAP12 expression — UCEC

Explore this box plot interactively →