THAP12

Across TCGA cell cohorts, THAP12 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,996 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible THAP12-associated GO terms across cancer lineages are Positive regulation of mitochondrial ATP synthesis coupled electron transport, Positive regulation of viral transcription, and Centriole elongation. Each is linked with THAP12 in more than 13 cancer types. Because this analysis shows association rather than direction, both THAP12-to-partner and partner-to-THAP12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of mitochondrial ATP synthesis coupled electron transport grouped by THAP12-low versus THAP12-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (THAP12→partner) and Y-score (partner→THAP12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Positive regulation of mitochondrial ATP synthesis coupled electron transport →	+0.094	+0.804	<.001	<.001	3	14
OESOPHAGUS	Positive regulation of viral transcription →	+0.181	+1.285	.001	.003	3	13
OESOPHAGUS	Centriole elongation →	+0.155	+1.512	<.001	<.001	3	13
OVARY	Establishment of mitotic sister chromatid cohesion →	+0.092	+0.761	<.001	<.001	3	13
BLOOD_Myeloma	Maintenance of organelle location →	+0.109	+0.919	<.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	Maintenance of Golgi location →	+0.123	+1.770	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,996 associations by consensus.

Positive regulation of mitochondrial ATP synthesis coupled electron transport by THAP12 expression — LARGE_INTESTINE

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