THAP12

Across TCGA cell cohorts, THAP12 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible THAP12-associated genes across cancer lineages are KHDRBS2, RXFP3, and ACER1. Each is linked with THAP12 in more than 1 cancer types. Because this analysis shows association rather than direction, both THAP12-to-partner and partner-to-THAP12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KHDRBS2 grouped by THAP12-low versus THAP12-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (THAP12→partner) and Y-score (partner→THAP12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	KHDRBS2 →	+0.603	+4.906	<.001	.006	3	1
OESOPHAGUS	RXFP3 →	+0.006	+4.906	<.001	.006	3	1
LARGE_INTESTINE	ACER1 →	+0.098	+3.823	.001	.006	3	1
BLOOD_Leukemia	KRTAP4-4 →	+0.016	+4.984	<.001	.002	3	1
BLOOD_Leukemia	KRT39 →	+0.184	+3.551	<.001	.009	3	1
BLOOD_Leukemia	PIRT →	+0.005	+3.874	.005	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

KHDRBS2 by THAP12 expression — OESOPHAGUS

Explore this box plot interactively →