THAP10

Across TCGA pan-cancer cohorts, THAP10 mass-spec protein differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of THAP10’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where THAP10 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types THAP10 is over-expressed in tumor, although a few such as CCRCC show the opposite, repressed pattern.

LSCC, CCRCC, and HNSC are the cancer types where THAP10 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in THAP10 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LSCC	All	All	+0.854	.026	3	view →
CCRCC	Male	II,III,IV	−0.572	<.001	2	view →
HNSC	All	IV	+0.447	.042	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

THAP10–LSCC

Open the LSCC breakdown →