THAP10

Across TCGA cell cohorts, THAP10 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,089 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible THAP10-associated GO terms across cancer lineages are Negative regulation of mitotic cell cycle, Regulation of spindle checkpoint, and Regulation of mitotic cell cycle spindle assembly checkpoint. Each is linked with THAP10 in more than 12 cancer types. Because this analysis shows association rather than direction, both THAP10-to-partner and partner-to-THAP10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of mitotic cell cycle grouped by THAP10-low versus THAP10-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (THAP10→partner) and Y-score (partner→THAP10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Negative regulation of mitotic cell cycle →	+0.082	+0.620	<.001	<.001	3	13
CNS	Regulation of spindle checkpoint →	+0.111	+0.765	<.001	<.001	3	12
BREAST	Regulation of mitotic cell cycle spindle assembly checkpoint →	+0.099	+0.537	<.001	.001	3	12
BREAST	Regulation of mitotic spindle checkpoint →	+0.099	+0.537	<.001	.001	3	12
BLOOD_Lymphoma	Regulation of myoblast fusion →	+0.100	+0.576	<.001	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	Negative regulation of cell cycle process →	+0.061	+0.538	.002	.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,089 associations by consensus.

Negative regulation of mitotic cell cycle by THAP10 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →