THAP10

Across TCGA cell cohorts, THAP10 mutation is significantly associated with the mutation status of many other genes, with 178 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible THAP10-associated genes across cancer lineages are PTPRE, EPS8L2, and CRHR1. Each is linked with THAP10 in more than 1 cancer types. Because this analysis shows association rather than direction, both THAP10-to-partner and partner-to-THAP10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PTPRE grouped by THAP10-low versus THAP10-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (THAP10→partner) and Y-score (partner→THAP10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PTPRE →	+4.000	+5.050	.008	.008	1	2
BLOOD_Leukemia	EPS8L2 →	+4.321	+5.285	.005	.005	1	2
BLOOD_Leukemia	CRHR1 →	+4.321	+5.285	.005	.005	1	2
BLOOD_Leukemia	IRAK3 →	+4.736	+5.560	.003	.003	1	2
LARGE_INTESTINE	OR5AK2 →	+4.523	+5.087	.006	.006	1	2
LARGE_INTESTINE	EBLN2 →	+4.523	+5.087	.006	.006	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 178 associations by consensus.

PTPRE by THAP10 expression — BLOOD_Leukemia

Explore this box plot interactively →