THADA

Across TCGA patient cohorts, THADA mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible THADA-associated genes across cancer lineages are FoxM1, ASNS, and Caspase-7-cleavedD198. Each is linked with THADA in more than 3 cancer types. Because this analysis shows association rather than direction, both THADA-to-partner and partner-to-THADA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by THADA-low versus THADA-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (THADA→partner) and Y-score (partner→THADA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	FoxM1 →	+0.192	+3.169	.043	.018	3	4
UCEC	ASNS →	+0.398	+2.415	<.001	.002	3	3
UCEC	Caspase-7-cleavedD198 →	+0.659	+1.827	<.001	.002	3	3
BLCA	Rictor_pT1135 →	-0.156	-3.169	.029	.019	3	2
UCEC	eIF4E →	+0.135	+2.013	.034	.004	3	2
UCEC	Notch1 →	+0.149	+1.453	<.001	.012	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

FoxM1 by THADA expression — SKCM

Explore this box plot interactively →