THADA

Across TCGA cell cohorts, THADA mutation is significantly associated with the RNA expression of many other genes, with 438 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible THADA-associated genes across cancer lineages are CFHR2, USP1, and KRT33B. Each is linked with THADA in more than 2 cancer types. Because this analysis shows association rather than direction, both THADA-to-partner and partner-to-THADA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CFHR2 grouped by THADA-low versus THADA-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (THADA→partner) and Y-score (partner→THADA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CFHR2 →	+0.125	+3.316	<.001	.003	3	3
LARGE_INTESTINE	USP1 →	+0.582	+2.451	.002	.009	3	3
BLOOD_Leukemia	KRT33B →	+0.015	+3.121	.001	<.001	3	2
BLOOD_Leukemia	OR2T1 →	+0.015	+3.316	<.001	.003	3	2
BLOOD_Leukemia	ARHGAP10 →	+1.197	+3.199	.002	.007	3	2
LARGE_INTESTINE	ERI3 →	+0.419	+3.169	.004	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 438 associations by consensus.

CFHR2 by THADA expression — BLOOD_Leukemia

Explore this box plot interactively →