THADA

Across TCGA cell cohorts, THADA mutation is significantly associated with the mutation status of many other genes, with 5,853 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible THADA-associated genes across cancer lineages are PRKCI, RIMS1, and ATRX. Each is linked with THADA in more than 4 cancer types. Because this analysis shows association rather than direction, both THADA-to-partner and partner-to-THADA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRKCI grouped by THADA-low versus THADA-high in KIDNEY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (THADA→partner) and Y-score (partner→THADA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	PRKCI →	+5.000	+5.000	.006	.006	1	5
KIDNEY	RIMS1 →	+5.000	+5.000	.006	.006	1	5
BONE	ATRX →	+3.655	+3.954	.003	.003	1	5
BLOOD_Leukemia	SCN4A →	+2.545	+2.545	.001	.001	1	5
UPPER_AERODIGESTIVE_TRACT	COL5A1 →	+3.023	+4.485	.001	.001	1	5
BLOOD_Lymphoma	DNAH2 →	+2.731	+3.289	.003	.003	1	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,853 associations by consensus.

PRKCI by THADA expression — KIDNEY

Explore this box plot interactively →