TH

Across TCGA patient cohorts, TH mutation is significantly associated with the RNA expression of many other genes, with 1,216 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TH-associated genes across cancer lineages are RNA5SP197, RN7SKP45, and DUX4L9. Each is linked with TH in more than 1 cancer types. Because this analysis shows association rather than direction, both TH-to-partner and partner-to-TH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP197 grouped by TH-low versus TH-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TH→partner) and Y-score (partner→TH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RNA5SP197 →	+0.818	+3.993	<.001	.005	3	2
COAD	RN7SKP45 →	+0.234	+5.136	<.001	.002	3	2
COAD	DUX4L9 →	+0.065	+3.951	.009	.005	3	2
COAD	LINC01758 →	+0.093	+5.824	.001	.001	3	2
SKCM	FCF1P3 →	+0.087	+3.207	.002	.001	3	2
CESC	RN7SL492P →	+0.175	+5.669	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,216 associations by consensus.

RNA5SP197 by TH expression — COAD

Explore this box plot interactively →