TH

Across TCGA patient cohorts, TH mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TH-associated genes across cancer lineages are eIF4E, JNK_pT183_Y185, and Myosin-IIa_pS1943. Each is linked with TH in more than 1 cancer types. Because this analysis shows association rather than direction, both TH-to-partner and partner-to-TH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by TH-low versus TH-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TH→partner) and Y-score (partner→TH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.209	+3.000	.040	.036	3	2
UCEC	JNK_pT183_Y185 →	-0.207	-2.446	.010	.020	3	1
UCEC	Myosin-IIa_pS1943 →	+0.204	+2.472	.041	.011	3	1
UCEC	p90 RSK →	+0.216	+3.331	.019	.005	3	1
UCEC	AMPK_pT172 →	+0.406	+2.472	.041	.011	3	1
UCEC	Rad50 →	-0.234	-2.459	.046	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

eIF4E by TH expression — UCEC

Explore this box plot interactively →