TH

Across TCGA cell cohorts, TH RNA expression is significantly associated with the go_rna of many other GO terms, with 1,237 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TH-associated GO terms across cancer lineages are Hyaloid vascular plexus regression, Tyrosine metabolic process, and Small GTPase-mediated signal transduction. Each is linked with TH in more than 6 cancer types. Because this analysis shows association rather than direction, both TH-to-partner and partner-to-TH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Hyaloid vascular plexus regression grouped by TH-low versus TH-high in STOMACH.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TH→partner) and Y-score (partner→TH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Hyaloid vascular plexus regression →	+1.393	+2.262	.002	<.001	3	7
UPPER_AERODIGESTIVE_TRACT	Tyrosine metabolic process →	-0.319	-0.776	<.001	<.001	3	5
PANCREAS	Small GTPase-mediated signal transduction →	+0.063	+1.949	<.001	.002	3	5
LUNG_NSCLC_LUAD	Vascular endothelial growth factor receptor signaling pathway →	+0.092	+0.852	.008	.003	3	5
OESOPHAGUS	Regulation of dendritic spine morphogenesis →	+0.118	+0.345	.004	.005	3	5
BLOOD_Lymphoma	Negative regulation of protein catabolic process →	+0.045	+0.027	<.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,237 associations by consensus.

Hyaloid vascular plexus regression by TH expression — STOMACH

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