TH

Across TCGA cell cohorts, TH mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TH-associated genes across cancer lineages are YIPF7, CTXN3, and LINGO4. Each is linked with TH in more than 1 cancer types. Because this analysis shows association rather than direction, both TH-to-partner and partner-to-TH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, YIPF7 grouped by TH-low versus TH-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TH→partner) and Y-score (partner→TH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	YIPF7 →	+0.066	+4.363	<.001	<.001	3	1
LARGE_INTESTINE	CTXN3 →	+0.455	+2.933	<.001	.003	3	1
LARGE_INTESTINE	LINGO4 →	+0.103	+3.584	.004	.004	3	1
SKIN	TMEM210 →	+0.059	+5.415	<.001	.004	3	1
BLOOD_Leukemia	OR51T1 →	+0.071	+4.922	<.001	.009	3	1
BLOOD_Leukemia	GSG1L2 →	+0.058	+5.969	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

YIPF7 by TH expression — LARGE_INTESTINE

Explore this box plot interactively →