TGS1

Across TCGA pan-cancer cohorts, TGS1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated TGS1 data layer compared with 25 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher TGS1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated TGS1 expression acts as an unfavorable survival marker, although some lineages such as LSCC and LUAD show a favorable association.

LSCC, LUAD, and CCRCC are the cancer types where TGS1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Tertile	All	1.000	0.661	<.001	41	view →
LUAD	DFS	Median	II,III,IV	0.742	0.309	.002	20	view →
CCRCC	DFS	Tertile	IV	0.173	0.861	.024	8	view →
PDAC	OS	Quartile	All	0.596	0.356	.038	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

TGS1–LSCC (OS)

Open the LSCC breakdown →