TGS1

Across TCGA cell cohorts, TGS1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,815 significant associations in total. BONE shows the largest number of these associations.

The most reproducible TGS1-associated GO terms across cancer lineages are RNA 5'-end processing, Double-strand break repair via homologous recombination, and Positive regulation of G2/M transition of mitotic cell cycle. Each is linked with TGS1 in more than 16 cancer types. Because this analysis shows association rather than direction, both TGS1-to-partner and partner-to-TGS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA 5'-end processing grouped by TGS1-low versus TGS1-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TGS1→partner) and Y-score (partner→TGS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	RNA 5'-end processing →	+0.089	+0.618	.001	<.001	3	17
SOFT_TISSUE	Double-strand break repair via homologous recombination →	+0.080	+0.735	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	Positive regulation of G2/M transition of mitotic cell cycle →	+0.125	+0.983	<.001	<.001	3	14
BONE	Regulation of DNA repair →	+0.094	+1.086	<.001	.001	3	14
SOFT_TISSUE	Double-strand break repair →	+0.073	+0.783	<.001	<.001	3	14
BONE	DNA-templated transcription initiation →	+0.091	+1.057	<.001	.005	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,815 associations by consensus.

RNA 5'-end processing by TGS1 expression — URINARY_TRACT

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