TGS1

Across TCGA cell cohorts, TGS1 mutation is significantly associated with the RNA expression of many other genes, with 33 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TGS1-associated genes across cancer lineages are RBMXL2, IL9, and SOX3. Each is linked with TGS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TGS1-to-partner and partner-to-TGS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RBMXL2 grouped by TGS1-low versus TGS1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TGS1→partner) and Y-score (partner→TGS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	RBMXL2 →	+0.062	+2.817	.003	.007	3	2
LIVER	IL9 →	+0.434	+3.977	<.001	.006	3	1
BLOOD_Leukemia	SOX3 →	+0.021	+4.551	<.001	.004	3	1
LUNG_NSCLC_LUAD	DEFB126 →	+0.489	+3.215	<.001	.007	3	1
LUNG_NSCLC_LUAD	RFPL3 →	+0.056	+3.807	.007	.004	3	1
LUNG_NSCLC_LUAD	CFHR4 →	+0.104	+4.188	.006	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

RBMXL2 by TGS1 expression — LARGE_INTESTINE

Explore this box plot interactively →