TGOLN2

Across TCGA patient cohorts, TGOLN2 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TGOLN2-associated genes across cancer lineages are eEF2, eIF4E, and JNK2. Each is linked with TGOLN2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TGOLN2-to-partner and partner-to-TGOLN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by TGOLN2-low versus TGOLN2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TGOLN2→partner) and Y-score (partner→TGOLN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.340	+2.321	.021	.033	3	2
UCEC	eIF4E →	+0.198	+2.321	.023	.006	3	2
UCEC	JNK2 →	+0.333	+2.594	<.001	.006	3	2
UCEC	PEA-15_pS116 →	+0.374	+1.700	.009	.042	3	2
UCEC	14-3-3_beta →	-0.094	-2.973	.023	.035	3	1
UCEC	A-Raf_pS299 →	-0.188	-3.584	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

eEF2 by TGOLN2 expression — UCEC

Explore this box plot interactively →