TGM5

Across TCGA patient cohorts, TGM5 protein abundance is significantly associated with the RNA expression of many other genes, with 3,753 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible TGM5-associated genes across cancer lineages are KRT16, SPINT3, and ZMIZ1. Each is linked with TGM5 in more than 1 cancer types. Because this analysis shows association rather than direction, both TGM5-to-partner and partner-to-TGM5 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TGM5 versus KRT16 in HNSC, with a Pearson correlation of 0.46.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TGM5→partner) and Y-score (partner→TGM5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	KRT16 →	+2.681	+0.821	<.001	.001	3	2
LSCC	SPINT3 →	-0.138	-0.975	.004	.008	3	1
LSCC	ZMIZ1 →	+0.576	+1.241	.003	.003	3	1
LSCC	KRT18 →	-1.444	-1.398	.002	.006	3	1
LSCC	GPRC5A →	-1.722	-1.678	.002	<.001	3	1
LSCC	PSMA5 →	-0.359	-1.478	.005	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,753 associations by consensus.

TGM5 vs KRT16 — HNSC

Explore this scatter interactively →