TGM5

Across TCGA patient cohorts, TGM5 mutation is significantly associated with the RNA expression of many other genes, with 2,412 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TGM5-associated genes across cancer lineages are GHITM, COQ3, and PGBD4P2. Each is linked with TGM5 in more than 2 cancer types. Because this analysis shows association rather than direction, both TGM5-to-partner and partner-to-TGM5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GHITM grouped by TGM5-low versus TGM5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TGM5→partner) and Y-score (partner→TGM5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GHITM →	+0.527	+2.807	.004	.003	3	3
UCEC	COQ3 →	+0.429	+2.595	.008	<.001	3	3
READ	PGBD4P2 →	+0.162	+6.257	<.001	.001	3	2
LGG	MBD3L3 →	+0.088	+5.846	<.001	.003	3	2
LGG	GIMD1 →	+0.243	+5.206	<.001	.007	3	2
SKCM	AXIN2 →	-0.713	-3.309	.002	.009	2	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,412 associations by consensus.

GHITM by TGM5 expression — UCEC

Explore this box plot interactively →