TGM5

Across TCGA patient cohorts, TGM5 mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. STAD shows the largest number of these associations.

The most reproducible TGM5-associated genes across cancer lineages are eIF4E, GAPDH, and GSK-3_pS9. Each is linked with TGM5 in more than 3 cancer types. Because this analysis shows association rather than direction, both TGM5-to-partner and partner-to-TGM5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by TGM5-low versus TGM5-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TGM5→partner) and Y-score (partner→TGM5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	eIF4E →	+0.213	+3.000	.022	.036	3	4
COAD	GAPDH →	+0.806	+3.182	<.001	.009	3	2
UCEC	GSK-3_pS9 →	-0.542	-2.321	.003	.034	3	2
STAD	GSK-3a-b_pS21_S9 →	-0.454	-3.000	.010	.036	3	2
STAD	MYH11 →	-2.054	-3.000	.007	.036	3	2
STAD	YAP_pS127 →	-0.340	-3.000	.043	.036	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

eIF4E by TGM5 expression — STAD

Explore this box plot interactively →