TGM5

Across TCGA cell cohorts, TGM5 mutation is significantly associated with the RNA expression of many other genes, with 64 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TGM5-associated genes across cancer lineages are MAGEB4, OR2T35, and NPHS2. Each is linked with TGM5 in more than 1 cancer types. Because this analysis shows association rather than direction, both TGM5-to-partner and partner-to-TGM5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAGEB4 grouped by TGM5-low versus TGM5-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TGM5→partner) and Y-score (partner→TGM5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MAGEB4 →	+0.011	+3.415	<.001	.001	3	2
BLOOD_Leukemia	OR2T35 →	+0.091	+3.684	<.001	.004	3	2
OESOPHAGUS	NPHS2 →	+0.007	+4.857	<.001	<.001	3	1
OESOPHAGUS	OR2F1 →	+0.016	+4.392	<.001	.003	3	1
BLOOD_Lymphoma	PRAMEF20 →	+0.415	+5.209	<.001	.005	3	1
LARGE_INTESTINE	A4GNT →	+0.062	+2.444	.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 64 associations by consensus.

MAGEB4 by TGM5 expression — LARGE_INTESTINE

Explore this box plot interactively →