TGM3

Across TCGA patient cohorts, TGM3 mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TGM3-associated genes across cancer lineages are Caspase-7-cleavedD198, ASNS, and A-Raf_pS299. Each is linked with TGM3 in more than 3 cancer types. Because this analysis shows association rather than direction, both TGM3-to-partner and partner-to-TGM3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by TGM3-low versus TGM3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TGM3→partner) and Y-score (partner→TGM3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.923	+2.999	<.001	<.001	3	4
UCEC	ASNS →	+0.403	+1.700	.001	.040	3	3
LUSC	A-Raf_pS299 →	+0.294	+2.468	.006	.011	3	2
UCEC	PCNA →	+0.264	+1.925	<.001	.005	3	2
UCEC	PDCD4 →	-0.561	-1.584	<.001	.019	3	2
UCEC	BRD4 →	+0.205	+2.321	.038	.033	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

Caspase-7-cleavedD198 by TGM3 expression — UCEC

Explore this box plot interactively →