TGM3

Across TCGA cell cohorts, TGM3 mutation is significantly associated with the RNA expression of many other genes, with 32 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TGM3-associated genes across cancer lineages are CSN2, CEACAM4, and OR13C5. Each is linked with TGM3 in more than 1 cancer types. Because this analysis shows association rather than direction, both TGM3-to-partner and partner-to-TGM3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CSN2 grouped by TGM3-low versus TGM3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TGM3→partner) and Y-score (partner→TGM3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CSN2 →	+0.020	+2.777	<.001	.004	3	2
PANCREAS	CEACAM4 →	+0.038	+4.237	<.001	.006	3	1
URINARY_TRACT	OR13C5 →	+0.760	+5.087	<.001	.004	3	1
BREAST	SLC17A2 →	+0.013	+5.781	<.001	.001	3	1
BREAST	RESP18 →	+0.072	+5.169	<.001	.005	3	1
LUNG_NSCLC_LUAD	PSKH2 →	+0.027	+4.472	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

CSN2 by TGM3 expression — LARGE_INTESTINE

Explore this box plot interactively →