TGM2

mutation — cross-omics
Cross-omicsMUTATION → PROTEIN-RPPAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, TGM2 mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TGM2-associated genes across cancer lineages are Caspase-7-cleavedD198, A-Raf_pS299, and INPP4B. Each is linked with TGM2 in more than 2 cancer types. Because this analysis shows association rather than direction, both TGM2-to-partner and partner-to-TGM2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TGM2→partner) and Y-score (partner→TGM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
COADCaspase-7-cleavedD198 →+1.403+3.016<.001.01833
UCECA-Raf_pS299 →-0.109-1.662.002.01032
COADINPP4B →-0.366-3.450.030.00532
UCECMEK1 →+0.365+2.321.001<.00132
UCECMSH2 →-0.236-1.821<.001.00732
UCECp27_pT198 →+0.083+1.473.010.00632
Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

Exploration