TGM1

Across TCGA patient cohorts, TGM1 mutation is significantly associated with the total protein of many other genes, with 55 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TGM1-associated genes across cancer lineages are Caspase-7-cleavedD198, 4E-BP1, and PDK1_pS241. Each is linked with TGM1 in more than 3 cancer types. Because this analysis shows association rather than direction, both TGM1-to-partner and partner-to-TGM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by TGM1-low versus TGM1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TGM1→partner) and Y-score (partner→TGM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.667	+2.189	<.001	.001	3	4
SKCM	4E-BP1 →	+0.398	+2.502	<.001	.001	3	3
COAD	PDK1_pS241 →	-0.179	-3.313	.023	.010	3	2
SKCM	FOXO3a_pS318_S321 →	-0.104	-2.982	.048	.034	3	2
SKCM	ACC1 →	+0.367	+2.000	.002	.009	3	2
SKCM	Rb_pS807_S811 →	+0.494	+2.000	.003	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 55 associations by consensus.

Caspase-7-cleavedD198 by TGM1 expression — UCEC

Explore this box plot interactively →