TGM1

Across TCGA cell cohorts, TGM1 mutation is significantly associated with the RNA expression of many other genes, with 45 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TGM1-associated genes across cancer lineages are IQCF5, CCL21, and ADIPOQ. Each is linked with TGM1 in more than 2 cancer types. Because this analysis shows association rather than direction, both TGM1-to-partner and partner-to-TGM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IQCF5 grouped by TGM1-low versus TGM1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TGM1→partner) and Y-score (partner→TGM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	IQCF5 →	+0.021	+3.700	<.001	.009	3	3
BLOOD_Lymphoma	CCL21 →	+0.322	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	ADIPOQ →	+0.006	+5.209	.006	.005	3	1
BLOOD_Lymphoma	OR8B3 →	+0.027	+5.209	.001	.005	3	1
BREAST	PNLIP →	+0.024	+4.421	.007	.004	3	1
BREAST	MRGPRX4 →	+0.352	+4.199	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

IQCF5 by TGM1 expression — LARGE_INTESTINE

Explore this box plot interactively →