Across TCGA pan-cancer cohorts, TGIF2P1 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of TGIF2P1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where TGIF2P1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TGIF2P1 is over-expressed in tumor, although a few such as THCA and LUAD show the opposite, repressed pattern.

HNSC, CHOL, and THCA are the cancer types where TGIF2P1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TGIF2P1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+0.106	.003	7	view →
CHOL	All	All	+0.253	.008	2	view →
THCA	Female	All	−0.076	.022	2	view →
LUAD	Male	All	−0.167	.009	1	view →
STAD	Male	IV	−0.145	.001	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: TGIF2P1 RNA expression & survival · all TGIF2P1 data types