TGIF2LX

Across TCGA patient cohorts, TGIF2LX mutation is significantly associated with the RNA expression of many other genes, with 988 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TGIF2LX-associated genes across cancer lineages are ATP6V1A, MIR7155, and SNORD116-26. Each is linked with TGIF2LX in more than 2 cancer types. Because this analysis shows association rather than direction, both TGIF2LX-to-partner and partner-to-TGIF2LX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATP6V1A grouped by TGIF2LX-low versus TGIF2LX-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TGIF2LX→partner) and Y-score (partner→TGIF2LX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATP6V1A →	+0.521	+2.700	.009	.006	3	3
UCEC	MIR7155 →	+0.364	+2.887	<.001	.003	3	3
CESC	SNORD116-26 →	+0.454	+4.269	<.001	.002	3	2
UCEC	RNA5SP423 →	+0.562	+2.065	.005	.005	3	2
CESC	MRPS22P1 →	+0.029	+6.000	<.001	<.001	3	2
UCEC	CREB3 →	+0.372	+3.064	.005	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 988 associations by consensus.

ATP6V1A by TGIF2LX expression — UCEC

Explore this box plot interactively →