TGIF2LX

Across TCGA patient cohorts, TGIF2LX mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TGIF2LX-associated genes across cancer lineages are 4E-BP1, eIF4E, and PCNA. Each is linked with TGIF2LX in more than 3 cancer types. Because this analysis shows association rather than direction, both TGIF2LX-to-partner and partner-to-TGIF2LX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by TGIF2LX-low versus TGIF2LX-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TGIF2LX→partner) and Y-score (partner→TGIF2LX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.285	+2.199	.019	.033	3	4
UCEC	eIF4E →	+0.204	+3.807	.032	<.001	3	3
UCEC	PCNA →	+0.224	+2.700	.021	.006	3	2
LUSC	Dvl3 →	+0.175	+3.321	.016	.009	3	2
UCEC	FOXO3a_pS318_S321 →	-0.123	-2.000	.029	.032	3	2
UCEC	JNK_pT183_Y185 →	-0.157	-3.000	.039	.036	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

4E-BP1 by TGIF2LX expression — UCEC

Explore this box plot interactively →