TGIF2LX

Across TCGA cell cohorts, TGIF2LX mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible TGIF2LX-associated genes across cancer lineages are C14orf177, SIRPD, and SERPINA2. Each is linked with TGIF2LX in more than 1 cancer types. Because this analysis shows association rather than direction, both TGIF2LX-to-partner and partner-to-TGIF2LX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C14orf177 grouped by TGIF2LX-low versus TGIF2LX-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TGIF2LX→partner) and Y-score (partner→TGIF2LX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	C14orf177 →	+0.055	+4.922	<.001	.009	3	1
LUNG_SCLC	SIRPD →	+0.065	+5.029	<.001	.006	3	1
LUNG_SCLC	SERPINA2 →	+0.045	+5.029	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

C14orf177 by TGIF2LX expression — BLOOD_Leukemia

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