TGIF2

Across TCGA patient cohorts, TGIF2 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TGIF2-associated genes across cancer lineages are IGFBP2, Myosin-IIa_pS1943, and Myosin-IIa. Each is linked with TGIF2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TGIF2-to-partner and partner-to-TGIF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IGFBP2 grouped by TGIF2-low versus TGIF2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TGIF2→partner) and Y-score (partner→TGIF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IGFBP2 →	-0.702	-2.807	.013	.003	3	1
UCEC	Myosin-IIa_pS1943 →	+0.228	+2.820	.011	.001	3	1
UCEC	Myosin-IIa →	+0.217	+2.122	.007	.010	3	1
UCEC	p27_pT157 →	-0.054	-3.282	.034	.010	3	1
UCEC	p90 RSK →	+0.186	+3.331	.026	.005	3	1
UCEC	PCNA →	+0.208	+2.999	.027	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

IGFBP2 by TGIF2 expression — UCEC

Explore this box plot interactively →