TGIF2

Across TCGA cell cohorts, TGIF2 mutation is significantly associated with the mutation status of many other genes, with 1,327 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TGIF2-associated genes across cancer lineages are ZBTB43, PRDM11, and ELAVL1. Each is linked with TGIF2 in more than 2 cancer types. Because this analysis shows association rather than direction, both TGIF2-to-partner and partner-to-TGIF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZBTB43 grouped by TGIF2-low versus TGIF2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TGIF2→partner) and Y-score (partner→TGIF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ZBTB43 →	+3.087	+4.392	.005	.005	1	3
LARGE_INTESTINE	PRDM11 →	+3.350	+4.584	.003	.003	1	2
LARGE_INTESTINE	ELAVL1 →	+3.672	+4.799	.002	.002	1	2
LARGE_INTESTINE	RHOA →	+3.672	+4.799	.002	.002	1	2
LARGE_INTESTINE	CDKL3 →	+3.350	+4.584	.003	.003	1	2
LARGE_INTESTINE	ALDH3A2 →	+3.672	+4.799	.002	.002	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,327 associations by consensus.

ZBTB43 by TGIF2 expression — LARGE_INTESTINE

Explore this box plot interactively →