TGIF1

Across TCGA cell cohorts, TGIF1 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,600 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible TGIF1-associated GO terms across cancer lineages are Negative regulation of hematopoietic stem cell differentiation, Nuclear-transcribed mRNA poly(A) tail shortening, and Regulation of cellular hyperosmotic salinity response. Each is linked with TGIF1 in more than 6 cancer types. Because this analysis shows association rather than direction, both TGIF1-to-partner and partner-to-TGIF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of hematopoietic stem cell differentiation grouped by TGIF1-low versus TGIF1-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TGIF1→partner) and Y-score (partner→TGIF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Negative regulation of hematopoietic stem cell differentiation →	+0.102	+0.631	.001	.001	3	7
KIDNEY	Nuclear-transcribed mRNA poly(A) tail shortening →	+0.074	+0.591	.006	<.001	3	7
LUNG_NSCLC_LUAD	Regulation of cellular hyperosmotic salinity response →	-0.128	-0.459	<.001	.002	3	7
LUNG_NSCLC_LUAD	Regulation of response to salt stress →	-0.128	-0.459	<.001	.002	3	7
BONE	Cellular response to glucagon stimulus →	-0.129	-1.385	.002	.002	3	7
PANCREAS	Regulation of vacuole organization →	+0.072	+1.147	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,600 associations by consensus.

Negative regulation of hematopoietic stem cell differentiation by TGIF1 expression — URINARY_TRACT

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