TGIF1

Across TCGA cell cohorts, TGIF1 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible TGIF1-associated genes across cancer lineages are IL2, LCE2B, and NLRP8. Each is linked with TGIF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TGIF1-to-partner and partner-to-TGIF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IL2 grouped by TGIF1-low versus TGIF1-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TGIF1→partner) and Y-score (partner→TGIF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	IL2 →	+0.032	+5.196	<.001	.005	3	1
OVARY	LCE2B →	+0.068	+5.196	<.001	.005	3	1
OVARY	NLRP8 →	+0.006	+5.196	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

IL2 by TGIF1 expression — OVARY

Explore this box plot interactively →