TGFBRAP1

Across TCGA pan-cancer cohorts, TGFBRAP1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated TGFBRAP1 data layer compared with 26 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher TGFBRAP1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated TGFBRAP1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and PDAC show a favorable association.

CCRCC, HNSC, and PDAC are the cancer types where TGFBRAP1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Tertile	III,IV	0.267	0.742	.001	23	view →
HNSC	OS	Tertile	All	0.964	0.374	.040	18	view →
PDAC	OS	Median	II,III,IV	0.971	0.755	.006	17	view →
LSCC	OS	Tertile	II,III,IV	0.947	1.000	.045	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

TGFBRAP1–CCRCC (DFS)

Open the CCRCC breakdown →