TGFBRAP1

Across TCGA patient cohorts, TGFBRAP1 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TGFBRAP1-associated genes across cancer lineages are Caspase-7-cleavedD198, eIF4E, and mTOR_pS2448. Each is linked with TGFBRAP1 in more than 2 cancer types. Because this analysis shows association rather than direction, both TGFBRAP1-to-partner and partner-to-TGFBRAP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by TGFBRAP1-low versus TGFBRAP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TGFBRAP1→partner) and Y-score (partner→TGFBRAP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.497	+2.584	.011	.010	3	3
UCEC	eIF4E →	+0.256	+2.263	<.001	<.001	3	2
UCEC	mTOR_pS2448 →	-0.100	-1.658	.041	.021	3	2
UCEC	14-3-3_epsilon →	+0.082	+1.425	.011	.027	3	2
UCEC	PDCD4 →	-0.417	-1.765	.007	.011	3	2
UCEC	ATM →	-0.462	-1.652	.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

Caspase-7-cleavedD198 by TGFBRAP1 expression — UCEC

Explore this box plot interactively →