TGFBRAP1

Across TCGA cell cohorts, TGFBRAP1 mutation is significantly associated with the RNA expression of many other genes, with 546 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TGFBRAP1-associated genes across cancer lineages are OR10J5, GLRA2, and LYG1. Each is linked with TGFBRAP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TGFBRAP1-to-partner and partner-to-TGFBRAP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10J5 grouped by TGFBRAP1-low versus TGFBRAP1-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TGFBRAP1→partner) and Y-score (partner→TGFBRAP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	OR10J5 →	+0.067	+4.754	<.001	<.001	3	2
BLOOD_Leukemia	GLRA2 →	+0.019	+4.639	<.001	<.001	3	2
LARGE_INTESTINE	LYG1 →	+0.702	+2.850	.004	<.001	3	2
LARGE_INTESTINE	ZNF18 →	+0.504	+3.459	.001	.001	3	2
LARGE_INTESTINE	REG1B →	+1.616	+1.833	<.001	.005	3	2
LARGE_INTESTINE	CTDNEP1 →	+0.516	+3.459	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 546 associations by consensus.

OR10J5 by TGFBRAP1 expression — BREAST

Explore this box plot interactively →