TGFBR3

Across TCGA pan-cancer cohorts, TGFBR3 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated TGFBR3 data layer compared with 23 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher TGFBR3 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated TGFBR3 expression acts as an unfavorable survival marker, although some lineages such as PDAC and HNSC show a favorable association.

PDAC, HNSC, and LUAD are the cancer types where TGFBR3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Tertile	III,IV	0.755	0.161	.026	13	view →
HNSC	DFS	Median	III,IV	1.000	0.905	.010	9	view →
LUAD	DFS	Median	All	0.938	0.494	.009	4	view →
GBM	OS	Quartile	All	0.275	0.645	.041	1	view →
CCRCC	DFS	Median	All	0.977	0.878	.026	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

TGFBR3–PDAC (OS)

Open the PDAC breakdown →