TGFBR3

Across TCGA patient cohorts, TGFBR3 mutation is significantly associated with the RNA expression of many other genes, with 2,334 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TGFBR3-associated genes across cancer lineages are CDCA8, HSPA9, and LETM1. Each is linked with TGFBR3 in more than 3 cancer types. Because this analysis shows association rather than direction, both TGFBR3-to-partner and partner-to-TGFBR3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CDCA8 grouped by TGFBR3-low versus TGFBR3-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TGFBR3→partner) and Y-score (partner→TGFBR3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	CDCA8 →	+0.476	+3.210	.009	.009	3	4
UCEC	HSPA9 →	+0.469	+2.353	<.001	<.001	3	4
COAD	LETM1 →	+0.556	+3.220	<.001	.009	3	3
LUAD	KCMF1 →	+0.495	+3.252	<.001	.009	3	3
LUAD	NBPF5P →	+0.083	+3.303	<.001	.002	3	3
UCEC	OIP5 →	+0.625	+2.338	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,334 associations by consensus.

CDCA8 by TGFBR3 expression — COAD

Explore this box plot interactively →