TGFBR3

Across TCGA patient cohorts, TGFBR3 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TGFBR3-associated genes across cancer lineages are Caspase-7-cleavedD198, p38-MAPK_pT180_Y182, and VHL. Each is linked with TGFBR3 in more than 3 cancer types. Because this analysis shows association rather than direction, both TGFBR3-to-partner and partner-to-TGFBR3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by TGFBR3-low versus TGFBR3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TGFBR3→partner) and Y-score (partner→TGFBR3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.528	+1.604	.006	.010	3	4
UCEC	p38-MAPK_pT180_Y182 →	-0.363	-1.440	.012	.022	3	2
UCEC	VHL →	-0.859	-1.459	<.001	.012	3	2
UCEC	c-Jun_pS73 →	-0.105	-1.797	.041	.025	3	2
UCEC	4E-BP1 →	+0.241	+2.459	.006	.018	3	2
LUSC	INPP4B →	+0.440	+2.834	.008	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

Caspase-7-cleavedD198 by TGFBR3 expression — UCEC

Explore this box plot interactively →