TGFBR3

Across TCGA cell cohorts, TGFBR3 mutation is significantly associated with the RNA expression of many other genes, with 116 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TGFBR3-associated genes across cancer lineages are CEACAM4, DCANP1, and OR5G3. Each is linked with TGFBR3 in more than 1 cancer types. Because this analysis shows association rather than direction, both TGFBR3-to-partner and partner-to-TGFBR3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CEACAM4 grouped by TGFBR3-low versus TGFBR3-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TGFBR3→partner) and Y-score (partner→TGFBR3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	CEACAM4 →	+1.430	+3.714	.005	.005	3	2
LARGE_INTESTINE	DCANP1 →	+0.007	+2.347	<.001	.007	3	2
PANCREAS	OR5G3 →	+0.043	+5.614	<.001	.002	3	1
LUNG_SCLC	TMEM82 →	+0.113	+3.523	<.001	.008	3	1
LUNG_SCLC	OPN1MW3 →	+0.008	+4.058	<.001	.007	3	1
URINARY_TRACT	OR6N1 →	+0.010	+4.087	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 116 associations by consensus.

CEACAM4 by TGFBR3 expression — BLOOD_Leukemia

Explore this box plot interactively →