TGFBR2

Across TCGA pan-cancer cohorts, TGFBR2 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated TGFBR2 data layer compared with 24 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher TGFBR2 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated TGFBR2 expression acts as an unfavorable survival marker, although some lineages such as HNSC and PDAC show a favorable association.

HNSC, PDAC, and LUAD are the cancer types where TGFBR2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	IV	0.890	0.462	.006	23	view →
PDAC	OS	Tertile	IV	0.973	0.490	.024	9	view →
LUAD	OS	Median	All	0.922	0.999	.016	7	view →
CCRCC	DFS	Median	All	0.944	0.886	.047	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

TGFBR2–HNSC (DFS)

Open the HNSC breakdown →