TGFBR2

Across TCGA patient cohorts, TGFBR2 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. COAD shows the largest number of these associations.

The most reproducible TGFBR2-associated genes across cancer lineages are ASNS, ACC1, and PCNA. Each is linked with TGFBR2 in more than 2 cancer types. Because this analysis shows association rather than direction, both TGFBR2-to-partner and partner-to-TGFBR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by TGFBR2-low versus TGFBR2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TGFBR2→partner) and Y-score (partner→TGFBR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	ASNS →	+0.511	+3.000	.039	.036	3	3
UCEC	ACC1 →	+0.299	+1.247	.015	.045	3	2
UCEC	PCNA →	+0.172	+2.321	.019	.033	3	2
UCEC	ATM →	-0.305	-1.514	.048	.015	3	2
COAD	eIF4E →	+0.306	+2.182	<.001	.033	3	2
COAD	FASN →	+0.609	+3.169	<.001	.018	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

ASNS by TGFBR2 expression — SKCM

Explore this box plot interactively →