TGFBR2

Across TCGA cell cohorts, TGFBR2 mutation is significantly associated with the RNA expression of many other genes, with 40 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TGFBR2-associated genes across cancer lineages are CLEC2A, PABPC1L2B, and RFX4. Each is linked with TGFBR2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TGFBR2-to-partner and partner-to-TGFBR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CLEC2A grouped by TGFBR2-low versus TGFBR2-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TGFBR2→partner) and Y-score (partner→TGFBR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	CLEC2A →	+0.733	+4.807	<.001	.006	3	2
BLOOD_Myeloma	PABPC1L2B →	+0.006	+4.807	<.001	.006	3	1
LARGE_INTESTINE	RFX4 →	+0.029	+2.252	.001	.005	3	1
LARGE_INTESTINE	CR2 →	+0.755	+3.726	<.001	<.001	3	1
LARGE_INTESTINE	MAP1S →	+0.678	+3.160	<.001	.006	3	1
LARGE_INTESTINE	C1orf162 →	+0.290	+3.537	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

CLEC2A by TGFBR2 expression — BLOOD_Myeloma

Explore this box plot interactively →