TGFBI

Across TCGA patient cohorts, TGFBI protein abundance is significantly associated with the RNA expression of many other genes, with 21,358 significant associations in total. GBM shows the largest number of these associations.

The most reproducible TGFBI-associated genes across cancer lineages are ACTA2, FN1, and COL5A1. Each is linked with TGFBI in more than 8 cancer types. Because this analysis shows association rather than direction, both TGFBI-to-partner and partner-to-TGFBI results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TGFBI versus ACTA2 in UCEC, with a Pearson correlation of 0.33.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TGFBI→partner) and Y-score (partner→TGFBI) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ACTA2 →	+1.836	+0.497	<.001	.003	3	9
BRCA	FN1 →	+1.519	+0.655	<.001	<.001	3	9
GBM	COL5A1 →	+1.445	+0.681	<.001	<.001	3	9
CCRCC	LOXL2 →	+1.095	+1.018	<.001	<.001	3	9
BRCA	MSRB3 →	+1.058	+0.668	<.001	<.001	3	9
OV	CAVIN1 →	+1.381	+0.710	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 21,358 associations by consensus.

TGFBI vs ACTA2 — UCEC

Explore this scatter interactively →